Molecular mechanisms and physiological roles of Atg5/Atg7-independent alternative autophagy
نویسندگان
چکیده
منابع مشابه
Molecular mechanisms and physiological roles of Atg5/Atg7-independent alternative autophagy
ATG5 and ATG7 are considered to be essential molecules for the induction of autophagy. However, we found that cells lacking ATG5 or ATG7 can still form autophagosomes/autolysosomes and perform autophagic protein degradation when subjected to certain types of stress. Although the lipidation of LC3 is accepted as a good indicator of autophagy, this did not occur during ATG5/ATG7-independent alter...
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Biological Roles of Alternative Autophagy
Atg5 and Atg7 have long been considered as essential molecules for autophagy. However, we found that cells lacking these molecules still form autophagic vacuoles and perform autophagic protein degradation when subjected to certain stressors. During this unconventional autophagy pathway, autophagosomes appeared to be generated in a Rab9-dependent manner by the fusion of vesicles derived from the...
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ژورنال
عنوان ژورنال: Proceedings of the Japan Academy, Series B
سال: 2017
ISSN: 0386-2208,1349-2896
DOI: 10.2183/pjab.93.023